She believed that injustice caused by racism will end when 'non-white people worldwide recognize, analyze, understand and discuss openly the genocidal dynamic.' She also tackled issues such as drug use, murder, teen pregnancy, infant mortality, incarceration, and unemployment, in the black community. The minority status of whites has caused what she calls a preoccupation with white genetic survival. According to Welsing, the genocide of people of color is caused by white people's inability to produce melanin.

In this book she talks about the genocide of people of color globally, along with issues black people in the United States face. Welsing specifically chose the name Isis for her admiration of 'truth and justice' that allowed for justice to be stronger than gold and silver. According to Welsing, all the names of the gods were significant however, also according to Welsing, Osiris means 'lord of the perfect Black,вЂќ although there is no etymological validity to this assertion. Isis was the sister/wife of the most significant god Osiris. The name 'The Isis Papers' was inspired by an ancient Egyptian goddess. The book is a compilation of essays that she had written over 18 years. In 1992, Welsing published The Isis Papers: The Keys to the Colors. Twenty-two years later she released The Isis Papers, a compilation of essays she had written about global and local race relations. This was an introduction to her thoughts that would be developed in The Isis Papers. The paper subsequently appeared in the May 1974 edition of the Black Scholar. While Welsing was an assistant professor at Howard University she formulated her first body of work in 1969, The Cress Theory of Color-Confrontation and self published it in 1970. and worked at many hospitals, especially children's hospitals. In the 1960s, Welsing moved to Washington, D.C. degree at Antioch College and in 1962 received an M.D. Cress, was a physician, and her mother, Ida Mae Griffen, was a teacher. Welsing was born Frances Luella Cress in Chicago on March 18, 1935.

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